The Future Of Cellular Protection & The Future Of Health

The Past

In the late 1960s, Dr. McCord, the scientist behind Protandim, discovered that the body produces its own protective enzyme called superoxide dismutase (SOD), which is able to counteract the cellular damage caused by free radicals. In the middle and late 1990s, researchers in Japan and around the world discovered that our cells possess an entire system of protective mechanisms that counteract cellular stress and slow the aging process.

The Present

At the very center of this cellular protective pathway is a protein called Nrf2 that serves as a “master regulator” of the body’s antioxidant response. Soon after Nrf2 was identified, a flurry of scientific discoveries began to show how Nrf2 also regulated genes involved in the production of not only a wide range of antioxidant enzymes (including SOD, glutathione, and catalase), but also important proteins, and detoxification or ‘‘stress-response’’ genes. They all share in common the Nrf2 “switch” that enables cells to protect themselves from both internal and external environmental challenges. In effect, Nrf2

activation enables our cells to make their own “medicines” to help us survive and thrive in stressful situations.

The Future

Many scientists believe that Nrf2 activation is the “future” of cellular protection and health promotion, and, in this regard, LifeVantage is clearly leading the way. This foundation of naturally activating Nrf2 to “solve” the problem of cellular stress is a fundamentally different way of restoring balance in the body, one that enables LifeVantage to effectively move into related areas of healthy living.


An onslaught of environmental stresses and biological assaults mounts over time, while our body’s ability to cope with these threats diminishes. This assault leads to disruption or failure in the function of individual cells or groups of cells.

To fight back, many people turn to high-dose antioxidant supplements and juices with so- called super fruits and vegetables. A growing body of research shows these high-dose, isolated, unbalanced antioxidant supplements can do more harm than good, actually promoting cellular stress, rather than protecting against it. Dietary antioxidants are limited, because they only work “1:1” meaning only one dietary antioxidant molecule is capable of neutralizing one free radical, a wholly inadequate strategy. They may be helpful to some small degree, but they’re incapable of sufficiently combating cellular stress. Taking antioxidants is not the best strategy—making the body’s own antioxidants is.


Protandim’s specific formula activates the Nrf2 protein, also known as a “master regulator” of the body’s stress response. Protandim stimulates this protein, resulting in the body producing its own powerful, protective antioxidant enzymes:superoxide dismutase, heme-oxygenase, glutathione peroxidase and catalase.

These enzymes function as potent antioxidants capable of neutralizing more than neutralizing more than one million free radicals or reactive oxygen species. It’s the synergy of ingredients in Protandim that are effective in activating the Nrf2 pathway.

There are other benefits of Nrf2 activation beyond cellular protection. Protandim helps the body repair and rejuvenate its own cells and detoxify genes, keeping the master blueprint of the cell’s function intact.

Protandim is the only supplement proven in a clinical study to reduce cellular stress by an average of 40% in 30 days. Protandim has been shown to increase superoxide dismutase levels by 30%, glutathione by 300%, and catalase by 54%. When individuals were supplemented with Protandim for 30 days, the age-dependent increase in lipid peroxidation was completely eliminated. Lipid peroxidation in an older subject was reduced to the level of a 20-year-old. This means the body is not only capable of making its own antioxidant enzymes, but also that their production can be activated by Protandim to reduce cellular stress and may help protect against the aging process and several conditions in which cellular stress has been reported to be a contributing factor.


Unlike high-dose antioxidant supplements, Protandim’s revolutionary formula is composed of a specific, proprietary ratio of plant extracts.

  • Tumeric
  • Bacopa
  • Piper Nigrum (Black Pepper Fruit extract)
  • Green Tea
  • Milk Thistle


Every Protandim tablet, bottle, package and lot is manufactured by LifeVantage to be safe and consistently standardized. To ensure unsurpassed product excellence, LifeVantage’s thorough quality control measures go beyond industry standards. LifeVantage rigorously tests every batch of both raw materials and finished goods for:

  • Identity
  • Potency
  • Microbial contamination
  • Pesticides/herbicides
  • Heavy metals

LifeVantage also routinely inspects manufacturing facilities and sends finished goods for third-party testing by industry leaders like the Banned Substances Control Group (BSCG) and NSF International.

BSCG and NSF symbols on the Protandim label assure consumers the product is free of substances banned by the World Anti- Doping Agency, meets label claim, is free of impurities, and has been produced utilizing federally mandated Good Manufacturing Practices.


In just the past few years, Protandim has been featured in reports by ABC, NBC, PBS, and The Wall Street Journal.

Protandim has been validated by numerous peer-reviewed studies. Some of these studies have been conducted at the following respected institutions:

  • Ohio State University
  • Louisiana State University
  • University of Colorado Denver
  • Virginia Commonwealth University
  • Colorado State University
  • Texas Tech University

The following peer-reviewed, scientific journals have published the results of these studies:

  • Free Radical Biology & Medicine
  • Enzyme Research
  • Circulation – the Scientific Journal of the American Heart Association
  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • PLoS One
  • Journal of Dietary Supplements
  • Molecular Aspects of Medicine
  • Enzyme Research
  • Oxidative Medicine and Cell Longevity
  • Exercise & Sports Science Reviews
  • Clinical Pharmacology